With training camp and preseason in the rearview, the 2025 NFL regular season kicks off on Thursday, September 4, as the defending champion Philadelphia Eagles host the Dallas Cowboys in the NFL Kickoff Game. The Week 1 NFL schedule is loaded with marquee matchups, and bettors are searching for the best opportunities to maximize returns. Point spread, point total, and moneyline bets remain staples, and uncovering true value in the Week 1 odds requires a deeper look. Before you make any Week 1 NFL picks, be sure to check out the NFL score predictions from the SportsLine computer simulation model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model went 31-15 on top-rated picks in 2024. Anybody following could have seen HUGE returns! Anyone following has seen HUGE returns!

After analyzing every game in Week 1, the model says the Commanders cover comfortably as 6-point home favorites against the Giants on Sunday. The Model rates a Commanders cover as an A-graded pick, predicting a final score of 32-21 in Washington's favor.

SportsLine's model has generated against the spread, over/under, and moneyline picks for every game in Week 1! In fact, the model has generated four HIGHLY-COVETED A-graded picks! You ABSOLUTELY NEED to see the Model's analysis before making any Week 1 NFL bets.

Which NFL bets do you need to make NOW for Week 1? And which must-see NFL picks are worthy of an A rating? ... Join SportsLine now to see the top 2025 Week 1 NFL picks, all from the SportsLine model that is up well over $7,000 for $100 players on top-rated NFL picks since its inception!